• In the short term, weight loss drugs may provide a
modest reduction in body weight (<5kg at 1 year;
See Table 1).
Whether long-term outcome
benefits will result is yet to be established.
• Sibutramine & Orlistat have been shown to reduce
and, to some extent, maintain weight loss.
{No additional benefit when agents combined.}
• Drug therapy alone is insufficient as trials also
included lifestyle modification co-interventions.
• Weight regain is common upon discontinuation.
